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André Mouraux - Principal investigator (IONS/COSY)

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Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Group members

Publications

2025

Strength, extent and duration of secondary hyperalgesia induced by high-frequency electrical stimulation of the foot compared to the volar forearm of healthy human volunteers

PLoS One

Lebrun L, Lenoir C, Leone C, van den Broeke EN, Caspani O, Schilder A, Pelz B, Truini A, Treede RD, Mouraux A

20(2):e0318934.

2025

A pain research strategy for Europe: A European survey and position paper of the European Pain Federation EFIC

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Eur J Pain

Pickering G, O'Keeffe M, Bannister K, Becker S, Cottom S, Cox FJ, Eisenberg E, Finn DP, Forget P, Graven-Nielsen T, Kalso E, Kocot-Kepska M, Leite-Almeida H, Lopez-Garcia JA, Meeus M, Mouraux A, Pereira B, Puljak L, Reneman MF, Rohde I, Sotiropoulos I, Skidmore N, Tölle TR, Todorovic ST, Truini A, Vowles KE, Pogatzki-Zahn E, Garcia-Larrea L, Fullen BM

29(1):e4767.

2024

Preoperative susceptibility to developing secondary hyperalgesia is associated with post‐thoracotomy pain at 2 months

Eur J Pain

Gousset S, Cappe M, Lenoir C, Steyaert A, Lavand'homme P, Mouraux A, Lacroix V, van den Broeke EN

29(1):e4768

2024

A multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activity

PLoS Biology

Nierula B, Stephani T, Bailey E, Kaptan M, Pohle LG, Horn U, Mouraux A, Maess B, Villringer A, Curio G, Nikulin VV, Eippert F.

22(10):e3002828.

2024

How visual experience shapes body representation

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Cognition

Shahzad I, Occelli V, Giraudet E, Azañón E, Longo MR, Mouraux A, Collignon O.

254:105980.

2024

Effect of limb position change on capsaicin-evoked pain: evidence of interplays between the vascular and nociceptive systems?

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Eur J Pain

Courtin AS, Knaepen, C, Mouraux A, van Neerven SGA

in press.

2024

Studying the effect of expectations on high-frequency electrical stimulation-induced pain and pinprick hypersensitivity

PDF

J Pain

Gousset S, Cayrol T, Papleux M, Meulders A, Mouraux A, van den Broeke EN

in press

2024

Systematic review and co-ordinate based meta-analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization

Eur J Pain

Clarke S, Rogers R, Wanigasekera V, Fardo F, Pia H, Nochi Z, Macian N, Leray V, Finnerup NB, Pickering G, Mouraux A, Truini A, Treede RD, Garcia-Larrea L, Tracey I.

in press.

2023

Modulation of the spinal N13 SEP component by high- and low-frequency electrical stimulation. Experimental pain models matter

Clinical Neurophysiology

Leone C, Di Pietro G, Salman Y, Galosi E, Di Stefano G, Caspani O, Garcia-Larrea L, Mouraux A, Treede RD, Truini A

156:28-37.

2023

Why Europe needs a pain research strategy

Eur J Pain

Pickering G, O'Keeffe M, Bannister K, Becker S, Cottom S, Cox FJ, Eisenberg E, Finn DP, Graven-Nielsen T, Meeus M, Mouraux A, Tölle T, Garcia-Larrea L, Fullen BM.

in press.

2023

Intra-operative electroencephalogram frontal alpha-band spectral analysis and postoperative delirium in cardiac surgery: A prospective cohort study

PDF

Eur J Anaesthesiol

Khalifa C, Lenoir C, Robert A, Watremez C, Kahn D, Mastrobuoni S, Aphram G, Ivanoiu A, Bonhomme V, Mouraux A, Momeni M.

40(10):777-787.

2023

Pinprick-induced gamma-band oscillations are not a useful electrophysiological marker of pinprick hypersensitivity in humans

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Clin Neurophysiol

Gousset S, Torta DM, Mouraux A, Lambert J, van den Broeke EN.

53:102-110.

2023

Poor pre-operative performance at Clock Drawing Test is associated with postoperative decline in olfaction in older patients: an observational pilot study

BMC Anesthesiology

Van Regemorter V, Coulie R, Dollase J, Momeni M, Stouffs A, Quenon L, Mouraux A, Huart C

23:295

2023

Influence of skin type and laser wavelength on laser evoked potentials

PDF

Eur J Pain

Frahm KS, Gervasio S, Arguissain F, Mouraux A

in press.

2023

Perceptual simultaneity between nociceptive and visual stimuli depends on their spatial congruence

Exp Brain Res

Manfron L, Filbrich L, Molitor V, Farnè A, Mouraux A, Legrain V

in press

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

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NOCIONS : PAIN RESEARCH AT UCLOUVAIN

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