NOCIONS all publications
NOCIONS all publications
Roberta Gualdani - Principal Investigator
My research project involves looking for recurrent TRP ion channel mutations in patients suffering from severe chronic pain, in order to understand whether there is a genetic predisposition to the development of the pain conditions, and to develop personalized therapies to normalize the activity of the mutant channels. To this end, I combine the most advanced state-of-the-art techniques for the biophysical and pharmacological study of ion channels, including electrophysiology, fluorescence spectroscopy, biochemistry, structural modelling. I have also a wide experience in ion channel drug discovery and in the development of genetically modified mouse models for in vivo experiments.
Group members
Publications
2018
Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA)
Front Mol Biosci
Tadini-Buoninsegni F, Smeazzetto S, Gualdani R, Moncelli MR.
5:36.
2018
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory
Front Cell Neurosci
Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.
12:318.
2018
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole
Cell Physiol Biochem
Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.
45(6):2233-2245.
2017
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX)
J Med Chem
Fragai M, Comito G, Di Cesare Mannelli L, Gualdani R, Calderone V, Louka A, Richichi B, Francesconi O, Angeli A, Nocentini A, Gratteri P, Chiarugi P, Ghelardini C, Tadini-Buoninsegni F, Supuran CT, Nativi C.
60(21):9003-9011.
2017
Discovery of a new mexiletine-derived agonist of the hERG K+ channel
Biophys Chem
Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Lentini G.
229:62-67.
2016
Recent Trends in the Discovery of Small Molecule Blockers of Sodium Channels
Curr Med Chem
Gualdani R, Cavalluzzi MM, Lentini G.
23(22):2289-332.
2016
The Chemistry and Pharmacology of Citrus Limonoids
Molecules
Gualdani R, Cavalluzzi MM, Lentini G, Habtemariam S.
21(11):1530.
2015
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine
Pharmacol Res Perspect
Gualdani R, Tadini-Buoninsegni F, Roselli M, Defrenza I, Contino M, Colabufo NA, Lentini G.
3(5):e00160.
2015
Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain
ACS Chem Neurosci
Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C.
6(3):380-5.
2013
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain. 2013 Dec;
Pain
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R.
154(12):2750-2758.
2013
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
Sci Rep
Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S.
3:2005.