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André Mouraux - Principal investigator (IONS/COSY)

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Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Publications

2023

The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking

Clinical Neurophysiology Practice

Pia H, Nochi Z, Kristensen AG, Pelz B, Goetz M, Hoeink JN, Blockeel AJ, Mouraux A, Truini A, Finnerup NB, Phillips KG, Treede RD, Tankisi H

8: 71-78.

2023

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Neural evidence for functional roles of tactile and visual feedback in the application of myoelectric prosthesis

J Neural Eng

Su S, Chai G, Xu W, Meng J, Sheng X, Mouraux A, Zhu X.

20(1).

2023

Spatial summation of cold and warm detection: evidence for increased precision when brisk stimuli are delivered over larger area

Neuroscience Letters

Courtin AS, Delvaux A, Dufour A, Mouraux A

in press.

2023

Confidence of probabilistic predictions modulates the cortical response to pain

PNAS

Mulders D, Seymour B, Mouraux A, Mancini F

in press.

2022

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High-speed heating of the skin using a contact thermode elicits comparable brain responses to those elicited by a CO2-laser device

Clin Neurophysiol

Lejeune N, Petrossova E, Frahm KS, Mouraux A.

146:1-9.

2022

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Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients

Brain Stimulation

Vespa S, Stumpp L, Liberati G, Delbeke J, Nonclercq A, Mouraux A, El Tahry R

in press.

2022

Investigating the Origin of TMS-evoked Brain Potentials Using Topographic Analysis.

Brain Topography

Sulcova D, Salatino A, Ivanoiu A, Mouraux A.

in press.

2022

No evidence for an effect of selective spatial attention on the development of secondary hyperalgesia: a replication study

Front Hum Neurosci

Della Porta D, Vila ML, Kuzminova A, Filbrich L, Mouraux A, Legrain V.

in press.

2022

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Chronic temporomandibular disorders are associated with higher susceptibility to developing central sensitization: a case-control study

Pain

Cayrol T, van den Broeke EN, Gerard E, Meeus M, Mouraux A, Roussel N, Pitance L.

in press.

2022

Olfactory dysfunction predicts frailty and poor postoperative outcome in older patients scheduled for elective non-cardiac surgery

J Nutr Health Aging

Van Regemorter V, Dollase J, Coulie R, Stouffs AD, de Saint-Hubert M, Mouraux A, Huart C.

in press.

2022

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Trials

Leone C, Di Stefano G, Di Pietro G, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Finnerup NB, Garcia-Larrea L, Li T, Goetz M, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Tracey I, Troconiz IF, Van Niel H, Hernandez JMV, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Truini A, Treede RD.

23(1):739.

2022

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

Int J Mol Sci

van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A* and Treede RD

23, 8295.

2022

Multichannel transcranial direct current stimulation over the left dorsolateral prefrontal cortex may modulate the induction of secondary hyperalgesia, a double-blinded cross-over study in healthy volunteers.

PLoS One

Steyaert A, Lenoir C, Lavand'homme P, van den Broeke EN, Mouraux A.

17(6):e0270047.

2022

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta-analysis

J Oral Rehabil

Cayrol T, Meeus M, Aron V, Gatto C, Mouraux A, Roussel NA, Sallaz L, van den Broeke EN, Pitance L.

49(6):654-670.

2022

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Trials

Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.

23(1):163.

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