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Sabien van Neerven - former postdoc (UCL MoveIn)

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The general objective of my project was to characterize the effects of topical capsaicin treatment on the changes in function and structure of nociceptive pathways associated with the development of chronic neuropathic pain and/or central sensitization. The project was translational, from bench to bedside, combining work performed in an animal model of neuropathic pain and work performed in patients suffering from chronic post-operative pain.

Publications

2024

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Effect of limb position change on capsaicin-evoked pain: evidence of interplays between the vascular and nociceptive systems?

Eur J Pain

Courtin AS, Knaepen, C, Mouraux A, van Neerven SGA

in press.

2020

Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber mediated heat sensitivity

Frontiers in Pharmacology

van Neerven SGA, Mouraux A.

0.885416667

2019

Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation

Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.

122(3):994-1001

2018

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Cell-enrichment with olfactory ensheathing cells has limited local extra beneficial effects on nerve regeneration supported by the nerve guide Perimaix

Journal of Tissue Engineering and Regenerative Medicine

Boecker AH, Bozkurt A, Kim BS, Altinova H, Tank J, Deumens R, Tolba R, Weis J, Brook GA, Pallua N, van Neerven S.

in press

2017

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Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

Journal of Neuroinflammation

Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.

14(1):209

2017

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Clinical and biometrical 12 months follow up study in patients after reconstruction of the sural nerve biopsy defect by the collagen-based nerve guide Neuromaix

European Journal of Medical Research

Bozkurt A, Claeys KG, Schrading S, Rose JV, Sellhaus B, Schulz JB, Weis J, Pallua N and van Neerven S.

22(1): 34

2016

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Functional recovery not correlated with axon regeneration through OEC-seeded scaffolds in a model of acute SCI

Journal of Tissue Engineering and Regenerative Medicine

Altinova H, Möllers S, Deumens R, Gerardo-Nava J, Führmann T, van Neerven S, Bozkurt A, Heschel I, Weis J, and Brook GA.

13(5): 585-600

2016

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Pre-differentiation of mesenchymal stromal cells in combination with a microstructured nerve guide supports peripheral nerve regeneration in the rat sciatic nerve model

European Journal of Neuroscience

Boecker AH, van Neerven S, Scheffel J, Tank J, Altinova H, Seidensticker K, Deumens R, Tolba R, Weis J, Brook GA, Pallua N and Bozkurt A.

43(3): 404-16

2016

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Efficient bridging of 20 mm rat sciatic nerve lesions with a longitudinally micro-structured collagen scaffold

Biomaterials

Bozkurt A, Boecker A, Tank J, Altinova H, Deumens R, Dabhi C, Tolba R, Weis J, Brook GA, Pallua N, van Neerven SG.

75:112-22

2016

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Two-component collagen nerve guides support axonal regeneration in the rat peripheral nerve injury model

Journal of Tissue Engineering and Regenerative Medicine

van Neerven SG, Haastert-Talini K, Boecker A, Schriever T, Dabhi C, Claeys K, Deumens R, Brook GA, Weis J, Pallua N, Bozkurt A.

2016

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Pre-differentiation of mesenchymal stromal cells in combination with a microstructured nerve guide supports peripheral nerve regeneration in the rat sciatic nerve model

European Journal of Neuroscience

Boecker AH, van Neerven SG, Scheffel J, Tank J, Altinova H, Seidensticker K, Deumens R, Tolba R, Weis J, Brook GA, Pallua N, Bozkurt A.

43(3):404-16

2014

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Human Schwann cells seeded on a novel collagen-based microstructured nerve guide survive, proliferate, and modify neurite outgrowth

BioMed Research International

van Neerven SG, Krings L, Haastert-Talini K, Vogt M, Tolba RH, Brook G, Pallua N, Bozkurt A.

2014:493823

2014

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Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study

Clinical Oral Implantations Research

Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers RD, Pallua N.

25(12):1403-11

2014

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The proximal medial sural nerve biopsy model: a standardised and reproducible baseline clinical model for the translational evaluation of bioengineered nerve guides

BioMed Research International

Bozkurt A, van Neerven SG, Claeys KG, ODey DM, Sudhoff A, Brook GA, Sellhaus B, Schulz JB, Weis J, Pallua N.

2014:121452

2013

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Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts

Neuroscience

van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R.

252:144-53

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